Tucson Symphony Center is located at 2175 N. Sixth Ave., one block south of Grant Road. The building houses the Tucson Symphony Orchestra administrative offices, the TSO Box Office, and a small performance space.

Parking is available in front of the building with entrances from the east on 6th Avenue or from the north on Rillito Street. When many visitors are expected, additional parking is opened behind the building, with an entrance on Rillito Street.

When leaving Tucson Symphony Center, be aware that travelers driving north on Sixth Avenue can only turn right onto eastbound Grant Road. Anyone who needs to travel west should drive west on Rillito Street and turn right onto Stone Avenue, which has turn lanes either direction onto Grant Road.